My study aimed to exploit rhizobia inoculation, phosphorus application, varietal differences and sequential cropping system to improve the productivity and profitability of cowpea per unit area in Minna, Nigeria. Glasshouse and field experiments were conducted between 2015 and 2017. The treatments evaluated during the study were: five rhizobial strains (USDA 3451, USDA 3384, BR 3262, BR 3267, control), three phosphorus rates (0, 20 and 40 kg P ha-1), six varieties of cowpea and soils were collected from 20 locations in Nigerian savannas.